Protective role of black cumin (Nigella sativa) on isoproterenol induced myocardial infarction in rats
نویسندگان
چکیده
Materials and methods: The rats were randomly divided into four groups of 6 rats each. Group 1 rats received 1.0 ml of 0.5% carboxymethyl cellulose (CMC) throughout the experimental period and served as the control. Group 2 rats received CMC as in group 1 and isoproterenol (85 mg/kg body weight) intraperitoneally twice at an interval of 24 hours on the 14th and 15th days. The rats in group 3 received black cumin (150 mg/kg body weight) intragastrically for a period of 15 days. Group 4 rats received black cumin and isoproterenol as said above and the experiment was terminated on 16th day and animals were sacrificed by cervical decapitation after an overnight fast. Blood was collected for the estimation of biochemical parameters and heart dissected out for biochemical estimation and histopathological examination.
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